Last year Windows announced it was removing support for U2F, a communication layer that allows Ledger to interact with web interfaces. Luckily, Ledger Nano supports multiple communication layers, including WebUSB, and WebBluetooth (on Nano X). Since most interfaces don't yet support WebBluetooth, we're going to be talking about connecting with WebUSB.
1. Update Windows
This might seem like a no brainer, but is actually extremely important. There are several drivers that have been known to cause issues with Ledger Nano (such as it getting stuck booting for several hours).
First search for Windows Update Settings
Then if you see any updates, restart now and update.
Note: If you’re upgrading to a “major” version of Windows 10, It may be necessary to download the Windows Update Assistant to install feature updates. (https://www.microsoft.com/software-download/windows10)
2. Update Ledger Nano firmware
Over the past year, there were a significant number of issues with firmware version 1.5.5 (on Ledger Nano S) not allowing windows users to connect. Make sure you update your firmware version to at least 1.6 for Ledger Nano S.
For Ledger Nano X, we recommend updating to the latest firmware version of at least 18.104.22.168.
Here is how to check your firmware version: https://support.ledger.com/hc/en-us/articles/360023346874-Check-the-firmware-version
And here's a video on how to upgrade (yes this video shows updating to firmware version 1.5.5 but make sure it shows 1.6 or greater).
Your cryptocurrency apps must also be up to date – this can be done by uninstalling and reinstalling them.
If you do not have the latest Firmware version and apps, you will not be able to access the web wallets.
3. Try it out!
If you correctly followed the steps above, you should have no trouble connecting your Ledger Nano S.
If you are using a Ledger Nano X, and you're still unable to connect, you may need to install some additional software that includes a driver that will allow you to connect.
3.1 Troubleshooting Ledger Nano X
Go ahead and download Zadig.
(Note, the Zadig version might be greater than 2.4. Install the latest version)
Go ahead and run the .exe
Now install the WCID Driver.
When this is finished, go back to the web interface you wanted to connect to, and plug in your Ledger Nano X.